Telegdy G, Kádár T, Balázs M
Institute of Pathophysiology, University Medical School Szeged, Hungary.
Pol J Pharmacol Pharm. 1990 Nov-Dec;42(6):537-46.
Investigations were made of the action of ACTH and LH-RH on a number of behavioural paradigms and the possible involvement of neurotransmitters or opiates by pretreatment of receptor blockers in rats and mice. ACTH delayed the extinction of active avoidance behaviour. Atropine and haloperidol blocked this action, whereas phenoxybenzamine and propranolol were ineffective. LH-RH or a highly potent analogue of LH-RH (D-Trp6-LH-RH) decreased the rate of disappearance of dopamine in the hypothalamus following alpha-methyl- paratyrosine inhibition of catecholamine synthesis, and blocked the accumulation of serotonin following MAO inhibition. LH-RH or the analogue attenuated the consolidation of passive avoidance learning. Apomorphine-induced cage-climbing was also inhibited by the LH-RH analogue, but this action was not influenced by naloxone. Open-field activity (ambulation, rearing and grooming) was decreased by the analogue peptide. Naloxone blocked the action on ambulation and rearing, but was ineffective on grooming. The LH-RH analogue caused a dose-dependent increase in cataleptogenic activity. This action could not be blocked with naloxone. The LH-RH analogue suppressed picrotoxin-induced seizures. Naloxone restored the situation to the control level. The data suggested that the effects of some neurohormones are mediated by transmitters or endogenous opiates, and that both peptide-transmitter and peptide-peptide interactions have to be considered in the action of neurohormones.
研究了促肾上腺皮质激素（ACTH）和促黄体生成素释放激素（LH-RH）对多种行为范式的作用，以及通过在大鼠和小鼠中预先使用受体阻滞剂来探究神经递质或阿片类物质的可能参与情况。ACTH延缓了主动回避行为的消退。阿托品和氟哌啶醇可阻断此作用，而酚苄明和普萘洛尔则无效。在α-甲基对酪氨酸抑制儿茶酚胺合成后，LH-RH或一种高效的LH-RH类似物（D-色氨酸6-LH-RH）降低了下丘脑中多巴胺的消失速率，并在单胺氧化酶（MAO）抑制后阻断了血清素的积累。LH-RH或该类似物减弱了被动回避学习的巩固。LH-RH类似物也抑制了阿扑吗啡诱导的笼内攀爬行为，但此作用不受纳洛酮影响。类似物肽降低了旷场活动（行走、站立和梳理毛发）。纳洛酮阻断了对行走和站立的作用，但对梳理毛发无效。LH-RH类似物导致致僵活性呈剂量依赖性增加。此作用不能被纳洛酮阻断。LH-RH类似物抑制了印防己毒素诱导的癫痫发作。纳洛酮将情况恢复到对照水平。数据表明，一些神经激素的作用是由递质或内源性阿片类物质介导的，并且在神经激素的作用中必须考虑肽-递质和肽-肽相互作用。
