Vécsei L, Bollók I, Telegdy G
Acta Physiol Hung. 1983;62(3-4):205-11.
Somatostatin administered intracerebroventricularly inhibited the extinction of active avoidance behaviour. The dopamine receptor blocking agent haloperidol, the alpha 1-receptor blocker phenoxybenzamine and the muscarinic anticholinergic agent atropine inhibited the behavioural effect of the peptide. Furthermore, somatostatin increased the locomotor activity of the animals. Neither of these drugs influenced the effect of the peptide exerted on locomotor activity. The peptide was ineffective on other parameters of the open-field test while phenoxybenzamine decreased the defecation rate of the animals and this effect was not influenced by somatostatin. The results suggest that the catecholaminergic and the cholinergic system play an important role in the inhibition of extinction produced by somatostatin but these mechanisms to not have a role in the locomotor activity induced by the peptide.
脑室内注射生长抑素可抑制主动回避行为的消退。多巴胺受体阻断剂氟哌啶醇、α1受体阻断剂酚苄明和毒蕈碱抗胆碱能剂阿托品可抑制该肽的行为效应。此外，生长抑素可增加动物的运动活性。这些药物均未影响该肽对运动活性的作用。该肽对旷场试验的其他参数无效，而酚苄明可降低动物的排便率，且该效应不受生长抑素的影响。结果表明，儿茶酚胺能系统和胆碱能系统在生长抑素产生的消退抑制中起重要作用，但这些机制在该肽诱导的运动活性中不起作用。
