Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, Oxford University, Oxford, UK.
Skin Res Technol. 2009 Nov;15(4):451-8. doi: 10.1111/j.1600-0846.2009.00389.x.
We propose that the distribution of skin lesions in psoriasis may be assessed using parametric maps on a pixel-by-pixel basis.
We processed 428 patient-drawn self-descriptions of the psoriasis lesions on a supplied body template. We compared 195 patients with a confirmed diagnosis of psoriatic arthritis (PsA) with 89 who had this diagnosis rejected (Psor). Additionally, 28 Psor cases supplied drawings performed after 3 weeks of climate therapy (PsorCT) to test the treatment efficacy. The drawings were scanned, lesion areas were segmented, followed by construction of parametric maps of lesion distributions and calculation of statistical differences between groups.
In PsorCT, the lesions occupied 11.2% (0-42%) [median (min.-max.)] of the body area. The area decreased to 2.4% (6-11%) after heliotherapy. The differences were statistically significant for all the areas studied and spread evenly over the body surface. PsA had a relatively low psoriasis lesion occupancy of 2.5% (0-42%) compared with Psor 9.8% (0-34%), which is attributed to the difference in recruitment. Correcting for this, we demonstrate a clear tendency for the head, palms, feet, groin and nails to be preferred lesion sites in PsA in contrast to psoriasis.
Pixel-based analysis of self-reported skin lesion distributions is a powerful tool to assess systematic differences due to treatment or disease variants.
我们提出可以通过逐点参数图来评估银屑病皮损的分布情况。
我们对 428 名患者在提供的身体模板上自行描述的银屑病皮损进行了处理。我们将 195 名确诊为银屑病关节炎（PsA）的患者与 89 名被排除该诊断的患者（Psor）进行了比较。此外，还对 28 名 Psor 患者在气候治疗 3 周后提供的皮损图进行了检测，以检验治疗效果。对这些皮损图进行扫描、分割皮损区域，然后构建皮损分布参数图，并计算组间的统计学差异。
在 PsorCT 中，皮损占身体面积的 11.2%（0-42%）[中位数（最小值-最大值）]。氦疗后，皮损面积减少至 2.4%（6-11%）。所有研究区域的差异均具有统计学意义，且均匀分布于体表。与 Psor（9.8%[0-34%]）相比，PsA 的银屑病皮损占有率相对较低，为 2.5%（0-42%），这归因于招募的差异。在纠正了这种差异后，我们发现 PsA 中头部、手掌、足底、腹股沟和指甲更倾向于出现皮损，这与银屑病不同。
基于像素的自我报告皮损分布分析是一种评估因治疗或疾病变异而导致的系统差异的有力工具。
