天然和合成木质素对培养的脾细胞的促有丝分裂活性。
Mitogenic activity of natural and synthetic lignins against cultured splenocytes.
作者信息
Kurakata Y, Sakagami H, Oh-Hara T, Kawazoe Y, Asano K, Fujinaga S, Takeda M, Sato T
机构信息
First Department of Biochemistry, School of Medicine, Showa University, Tokyo, Japan.
出版信息
In Vivo. 1990 Nov-Dec;4(6):377-80.
Various natural lignified materials and synthetic dehydrogenation polymers (the so-called synthetic lignins) prepared from several phenylpropenoids were investigated for their mitogenic activity. All of these materials time- and dose-dependently stimulated the DNA synthesis of isolated mouse splenocytes. However, their stimulating activity was significantly decreased when the splenocytes were pretreated with anti-Thy-1.2 monoclonal antibody and rabbit complement. Natural and synthetic lignins demand attention as potential immunopotentiators.
对多种天然木质化材料以及由几种苯丙素类化合物制备的合成脱氢聚合物（即所谓的合成木质素）的促有丝分裂活性进行了研究。所有这些材料均呈时间和剂量依赖性地刺激分离的小鼠脾细胞的DNA合成。然而，当脾细胞用抗Thy-1.2单克隆抗体和兔补体进行预处理时，它们的刺激活性显著降低。天然和合成木质素作为潜在的免疫增强剂值得关注。
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