Kikuchi K, Sakagami H, Fujinaga S, Kawazoe Y, Oh-Hara T, Ichikawa S, Kurakata Y, Takeda M, Sato T
First Department of Biochemistry, School of Medicine, Showa University, Tokyo, Japan.
Anticancer Res. 1991 Mar-Apr;11(2):841-5.
Various lignified materials, including pine cone extract and a commercial lignin, stimulated the morphological change (spreading) of mouse peritoneal macrophages, and their functional maturation as judged by increase in NBT-reducing activity. When these materials were treated with NaClO2 to decompose the phenolic structure, their activity was completely eliminated, whereas the activity was rather enhanced when they were treated with H2SO4 to decompose their sugar moiety. Some monomeric phenolic compounds structurally related to lignin components and several antitumor glucan derivatives had little or no macrophage stimulating activity. The results strongly suggest the importance of lignin-structure in macrophage activation.
包括松果提取物和一种商业木质素在内的各种木质化材料，刺激了小鼠腹腔巨噬细胞的形态变化（铺展），并且根据NBT还原活性的增加判断，它们的功能也成熟了。当用NaClO2处理这些材料以分解酚结构时，它们的活性完全消除，而当用H2SO4处理以分解其糖部分时，活性反而增强。一些与木质素成分结构相关的单体酚类化合物和几种抗肿瘤葡聚糖衍生物几乎没有或没有巨噬细胞刺激活性。结果强烈表明木质素结构在巨噬细胞激活中的重要性。
