Bigal Marcelo
Merck Research Laboratory, Whitehouse Statoin, New Jersey 08889, United States.
Discov Med. 2009 Oct;8(42):145-50.
Migraine is a chronic disease with episodic attacks and a variable prognosis. In a subgroup, migraine evolves into a more protracted condition (migraine transformation or progression). Transformation of migraine may be subdivided into three partially overlapping forms. Clinical transformation describes the evolution from episodic into chronic migraine. Physiological transformation refers to alterations in nociceptive thresholds and in pain pathways that precede or accompany clinical transformation. Anatomical transformation refers to the emergence of definitive brain lesions (e.g., stroke and deep white matter lesions) in some migraineurs. Herein we conceptualize migraine as a progressive disease and discuss risk factors for transformation.
偏头痛是一种具有发作性且预后不定的慢性疾病。在一个亚组中，偏头痛会演变成一种更持久的病症（偏头痛转变或进展）。偏头痛的转变可细分为三种部分重叠的形式。临床转变描述了从发作性偏头痛到慢性偏头痛的演变。生理转变是指在临床转变之前或伴随临床转变出现的伤害性感受阈值和疼痛通路的改变。解剖学转变是指在一些偏头痛患者中出现明确的脑部病变（如中风和深部白质病变）。在此，我们将偏头痛概念化为一种进行性疾病，并讨论其转变的危险因素。
