Grazzi Licia, D'Amico Domenico, Raggi Alberto, Leonardi Matilde, Ciusani Emilio, Corsini Elena, D'Andrea Giovanni, Bolner Andrea, Salgado-García Francisco, Andrasik Frank, Sansone Emanuela
Headache and Neuroalgology Unit, Neurological Institute "C. Besta" IRCCS Foundation, Via Celoria 11, 20133, Milan, Italy.
Neurology, Public Health and Disability Unit, Neurological Institute "C. Besta" IRCCS Foundation, Milan, Italy.
Neurol Sci. 2017 May;38(Suppl 1):173-175. doi: 10.1007/s10072-017-2874-0.
Chronic migraine (CM) is a disabling condition arising from a complex mixture of interconnected biological, psychological and social factors, and is often associated with medication overuse (MO). Mindfulness is emerging as a helpful treatment for pain, and one study showed that the longitudinal 12 months' course of CM-MO patients that attended mindfulness-based treatment alone was similar to that of patients receiving medical prophylaxis alone; in this study, we describe the course of biomarkers of inflammation. Our results provide initial evidence of sustained similar effects on reduced concentration of biomarkers of inflammation, although not sizeable enough to reach statistical significance. Whether more intensive treatment and/or larger samples would lead to greater changes is unknown, but these encouraging preliminary findings suggest further research is warranted.
慢性偏头痛（CM）是一种由相互关联的生物、心理和社会因素复杂混合引发的致残性疾病，且常与药物过度使用（MO）相关。正念正逐渐成为一种有效的疼痛治疗方法，一项研究表明，仅接受基于正念治疗的CM-MO患者的12个月纵向病程与仅接受药物预防的患者相似；在本研究中，我们描述了炎症生物标志物的变化过程。我们的结果提供了初步证据，表明对炎症生物标志物浓度降低有持续的相似影响，尽管幅度不足以达到统计学显著性。更强化的治疗和/或更大的样本量是否会导致更大的变化尚不清楚，但这些令人鼓舞的初步发现表明有必要进行进一步研究。
