Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
Stroke. 2009 Dec;40(12):e678-82. doi: 10.1161/STROKEAHA.109.565838. Epub 2009 Oct 15.
Autonomic dysfunction, including increased sympathetic drive and blunted baroreflex, has repeatedly been observed in acute stroke. Of clinical importance is that the stroke-related autonomic imbalance seems to be linked to worse outcome after stroke. Here, we discuss the role of baroreflex impairment in acute stroke and its possible pathophysiological and therapeutic relevance. Summary of Review- Possible mechanisms linking baroreflex impairment with unfavorable outcome in stroke may include increased cardiovascular morbidity and mortality, promotion of secondary brain injury due to local inflammation, hyperglycemia, or altered cerebral perfusion.
We suggest therefore that the modifying of autonomic functions may have important therapeutic implications in acute ischemic as well as in hemorrhagic stroke.
在急性中风中，反复观察到自主神经功能障碍，包括交感神经驱动增加和压力反射迟钝。从临床重要性上讲，中风相关的自主神经失衡似乎与中风后的不良预后有关。在这里，我们讨论了压力反射受损在急性中风中的作用及其可能的病理生理和治疗相关性。综述摘要-可能将压力反射受损与中风不良预后联系起来的机制包括心血管发病率和死亡率增加、局部炎症、高血糖或改变脑灌注引起的继发性脑损伤。结论：因此，我们建议，自主功能的调节可能对急性缺血性和出血性中风具有重要的治疗意义。
