Vanderheyden J L
GE Healthcare, Healthcare Systems, Molecular Imaging, Waukesha, WI, USA.
Q J Nucl Med Mol Imaging. 2009 Aug;53(4):374-81.
Molecular imaging tools, both equipment and agents, continue to improve and evolve, offering multimodality imaging with greater sensitivity and high-resolution of biological processes in real time. This review summarizes some of these recent developments in preclinical hardware, wetware and software, and their impact on drug development. The focus is on the advances in non-invasive small animal imaging such as positron emission tomography (PET), computed tomography (CT) and solid state detectors in single photon emission tomography (SPECT), which, when combined with labeled tracers serving as biomarkers and functional probes in vivo, are demonstrating the potential to accelerate our understanding of disease and help select drug candidates for development.
分子成像工具，包括设备和试剂，一直在不断改进和发展，能够提供多模态成像，以更高的灵敏度和高分辨率实时观察生物过程。本综述总结了临床前硬件、软件和湿件方面的一些最新进展，以及它们对药物开发的影响。重点是无创小动物成像的进展，如正电子发射断层扫描（PET）、计算机断层扫描（CT）和单光子发射计算机断层扫描（SPECT）中的固态探测器，当与用作体内生物标志物和功能探针的标记示踪剂相结合时，显示出加速我们对疾病的理解并有助于选择候选药物进行开发的潜力。
