SC Clinica Medica Generale e Terapia Medica, Università degli Studi di Trieste, Ospedale di Cattinara, Trieste, Italy.
Arch Gerontol Geriatr. 2009;49 Suppl 1:83-94. doi: 10.1016/j.archger.2009.09.016.
Remodeling of skeletal muscles is regulated by matrix metalloproteinases (MMPs). Functional genetic polymorphism (PM), modulating the expression of some MMPs, might be associated to different body composition and muscular strength improvement after exercise. Genetic PM of MMP-1 (G+/- at -1607), MMP-3 (5A/6A at -1171) and MMP-9 (Cytosine-Adenine microsatellite=(13-27)CA) repeats, around -90), body cell mass (BCM), extracellular water (ECW) and isometric maximal extensor strength (MES) of both legs were determined in 17 old sedentary women at the beginning and at the end of a 24 week physical exercise program. A 12 and 72% increase in BCM and MES, respectively, and 11% reduction in ECW were observed at the end of the program. Carriers of G-insertion in MMP-1, PM increased their BCM (7 kg vs. -1.5, p=0.007) and lost ECW (9% of total body water vs. 0.1%, p=0.004) more than the non-carriers; homozygote for 21 or less CA repeats/allele in MMP-9 PM gained more MES (115 N, interquartile range=IQR=63-132) than carriers of longer microsatellites (63 N, IQR=40-86, p=0.028). MMP-3 did not show any association with body composition and exercise-related strength changes. Exercise in elderly women increases BCM and strength, these changes are associate to specific MMP genotypes.
骨骼肌的重塑受基质金属蛋白酶（MMPs）调节。功能遗传多态性（PM），调节某些 MMPs 的表达，可能与运动后不同的身体成分和肌肉力量改善有关。MMP-1（-1607 处的 G+/ -）、MMP-3（-1171 处的 5A/6A）和 MMP-9（胞嘧啶-腺嘌呤微卫星=（13-27）CA）重复的遗传 PM （-90 处周围）、细胞内液（BCM）、细胞外液（ECW）和等长最大伸肌强度（MES）在 17 名久坐不动的老年女性在开始和结束 24 周的体育锻炼计划时进行了测定。在该计划结束时，BCM 和 MES 分别增加了 12%和 72%，ECW 减少了 11%。MMP-1 中的 G-插入的载体，PM 增加了他们的 BCM（7 公斤对 -1.5，p=0.007）和失去 ECW（9%的总身体水分对 0.1%，p=0.004）比非载体多；MMP-9 PM 中 21 个或更少的 CA 重复/等位基因的纯合子获得了更多的 MES（115 N，四分位间距=IQR=63-132）比携带较长微卫星的载体（63 N，IQR=40-86，p=0.028）。MMP-3 与身体成分和与运动相关的力量变化没有任何关联。老年女性的运动增加了 BCM 和力量，这些变化与特定的 MMP 基因型有关。
