Dipartimento di Scienze dell'Invecchiamento, Sapienza Universita di Roma, Umberto I Policlinico di Roma, Roma, Italy.
Arch Gerontol Geriatr. 2009;49 Suppl 1:95-101. doi: 10.1016/j.archger.2009.09.017.
This study compares the efficacy of telmisartan with that of valsartan and ramipril in reducing blood pressure (BP) over 24 hrs in the elderly patients with metabolic syndrome (MS). This prospective and open label study analyzed a sample of 60 patients over 65 years of age with hypertension and with MS. At the beginning the BP was monitored by a 24-hr ambulatory blood pressure monitoring (AMBP). Following this, the 60 patients were divided into 3 groups of 20, to each of which was prescribed, respectively, telmisartan, valsartan and ramipril to take for 12 weeks. The drugs were to be taken at 9.00 a.m. Later on the doses were increased. After 12 weeks of therapy, BP was monitored by a 24-hr AMBP. The use of telmisartan caused a greater reduction of the BP in the final 4-6 hours of the period between the 1st administration of the drug and the next one, these last 4-6 hours being those when cardiovascular and cerebrovascular accidents are more frequent (between 6.00 and 10.00 a.m.). Comparing to valsartan and ramipril, telmisartan results in excellent pressure control during the last 4-6 hours between the 1st administration of the drug and the next one.
本研究比较了替米沙坦与缬沙坦和雷米普利在老年代谢综合征（MS）患者 24 小时内降低血压（BP）的疗效。这项前瞻性、开放标签研究分析了 60 名年龄在 65 岁以上的高血压合并 MS 患者的样本。首先，通过 24 小时动态血压监测（ABPM）监测血压。在此之后，将 60 名患者分为 3 组，每组 20 人，分别给予替米沙坦、缬沙坦和雷米普利治疗 12 周。药物在上午 9 点服用。之后增加剂量。治疗 12 周后，通过 24 小时 ABPM 监测血压。替米沙坦的使用导致在药物首次给药和下一次给药之间的最后 4-6 小时内血压降低更大，这些最后 4-6 小时是心血管和脑血管意外更频繁发生的时间（上午 6 点至 10 点）。与缬沙坦和雷米普利相比，替米沙坦在药物首次给药和下一次给药之间的最后 4-6 小时内，血压控制效果极佳。
