Iatta Roberta, Napoli Christian, Borghi Elisa, Montagna Maria Teresa
Department of Biomedical Science and Human Oncology, University of Bari, Bari, Italy.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Nov;108(5):647-55. doi: 10.1016/j.tripleo.2009.07.010.
Stomatologic fungal infections display different etiologies, pathogenesis, and clinical presentations. The incidence of rare mycoses of oral cavity is very low. These infections can involve both immunocompromised and immmunocompetent patients with common predisposing factors, such as diabetes or suffering from diseases causing immune system impairment. Oral mycoses can cause acute, chronic, and mucocutaneous lesions. Candidiasis is the most common mouth mycosis. Although occasionally primary mouth pathogens, Cryptococcus spp. or filamentous fungi (Aspergillus spp. and zygomycetes) can cause oral mycoses, with the oral localization more commonly secondary to a more serious systemic infection. The diagnosis of oral mycoses is based on clinical examination; for yeasts, culture is necessary to identify the etiologic agents; for filamentous fungi, in particular for zygomycetes and dimorphic, a definitive diagnosis can be made by histologic examination and pertinent stains with or without isolation of the fungus from the same site.
口腔真菌感染表现出不同的病因、发病机制和临床表现。口腔罕见真菌病的发病率很低。这些感染可累及免疫功能低下和免疫功能正常的患者,他们通常有一些易感因素,如糖尿病或患有导致免疫系统受损的疾病。口腔真菌病可引起急性、慢性和黏膜皮肤病变。念珠菌病是最常见的口腔真菌病。虽然隐球菌属或丝状真菌(曲霉属和接合菌)偶尔是原发性口腔病原体,但它们也可引起口腔真菌病,且口腔局部感染更常见于继发于更严重的全身感染。口腔真菌病的诊断基于临床检查;对于酵母菌,需要进行培养以鉴定病原体;对于丝状真菌,特别是接合菌和双相真菌,可通过组织学检查和相关染色进行明确诊断,无论是否从同一部位分离出真菌。