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一条新的延髓通路的激活引发豚鼠迷走神经介导的胆碱能性支气管收缩。

Activation of a novel medullary pathway elicits a vagal, cholinergic bronchoconstriction in guinea-pigs.

作者信息

Hey J A, del Prado M, Chapman R W

机构信息

Department of Allergy and Inflammation, Schering-Plough Research, New Jersey 07003.

出版信息

Pulm Pharmacol. 1990;3(1):53-4. doi: 10.1016/0952-0600(90)90010-g.

DOI:10.1016/0952-0600(90)90010-g
PMID:1983733
Abstract

Electrical stimulation of structures within the rostral region of the dorsal medulla of the guinea-pig activates a vagal cholinergic bronchoconstriction pathway and simultaneously activates a sympathetic inhibitory input. Removal of the latter by spinal section potentiated CNS-induced bronchospasm.

摘要

对豚鼠延髓背侧吻侧区域内的结构进行电刺激,会激活一条迷走胆碱能支气管收缩途径,同时激活一条交感抑制性传入神经。通过脊髓横断术去除后者会增强中枢神经系统诱导的支气管痉挛。

相似文献

1
Activation of a novel medullary pathway elicits a vagal, cholinergic bronchoconstriction in guinea-pigs.一条新的延髓通路的激活引发豚鼠迷走神经介导的胆碱能性支气管收缩。
Pulm Pharmacol. 1990;3(1):53-4. doi: 10.1016/0952-0600(90)90010-g.
2
Possible roles of the peripheral vagal nerve in histamine-induced bronchoconstriction in guinea-pigs.外周迷走神经在组胺诱导的豚鼠支气管收缩中的可能作用。
Eur Respir J. 1991 Jul;4(7):860-6.
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Ganglion-blocking agents enhance neurally mediated bronchoconstriction in the guinea-pig: possible role of sensory neuropeptides.神经节阻断剂增强豚鼠神经介导的支气管收缩:感觉神经肽的可能作用。
Eur J Pharmacol. 1990 May 16;180(2-3):239-45. doi: 10.1016/0014-2999(90)90307-r.
4
Ipratropium bromide potentiates bronchoconstriction induced by vagal nerve stimulation in the guinea-pig.
Eur J Pharmacol. 1987 Jul 9;139(2):187-91. doi: 10.1016/0014-2999(87)90251-2.
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(R)-alpha-methylhistamine augments neural, cholinergic bronchospasm in guinea pigs by histamine H1 receptor activation.(R)-α-甲基组胺通过激活组胺H1受体增强豚鼠的神经性胆碱能性支气管痉挛。
Eur J Pharmacol. 1992 Feb 18;211(3):421-6. doi: 10.1016/0014-2999(92)90401-o.
6
Evidence that distinct neural pathways mediate parasympathetic contractions and relaxations of guinea-pig trachealis.有证据表明,不同的神经通路介导豚鼠气管的副交感神经收缩和舒张。
J Physiol. 1993 Nov;471:25-40. doi: 10.1113/jphysiol.1993.sp019889.
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[Mechanism of acceleration of myocardial contractions caused by stimulation of vagus nerve ganglia in frogs].[蛙迷走神经节刺激引起心肌收缩加速的机制]
Biull Eksp Biol Med. 1997 Jul;124(7):16-20.
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Relaxant innervation of the guinea-pig trachealis: demonstration of capsaicin-sensitive and -insensitive vagal pathways.豚鼠气管的舒张性神经支配:辣椒素敏感和不敏感迷走神经通路的证明。
J Physiol. 1993 Jan;460:719-39. doi: 10.1113/jphysiol.1993.sp019496.
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Effects of prostaglandin E2 on ganglionic transmission in the guinea pig trachea.前列腺素E2对豚鼠气管神经节传递的影响。
Respir Physiol. 1992 Jan;87(1):131-9. doi: 10.1016/0034-5687(92)90105-6.
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Vagal stimulation induces increased pulmonary vascular permeability in guinea pig.
Am J Respir Crit Care Med. 1994 Mar;149(3 Pt 1):744-50. doi: 10.1164/ajrccm.149.3.7906995.

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Bradykinin-induced airflow obstruction and airway plasma exudation: effects of drugs that inhibit acetylcholine, thromboxane A2 or leukotrienes.缓激肽诱导的气流阻塞和气道血浆渗出:抑制乙酰胆碱、血栓素A2或白三烯的药物的作用
Br J Pharmacol. 1993 Oct;110(2):657-64. doi: 10.1111/j.1476-5381.1993.tb13862.x.
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Pulmonary function survey in spinal cord injury: influences of smoking and level and completeness of injury.脊髓损伤患者的肺功能调查:吸烟、损伤平面及损伤完整性的影响
Lung. 1995;173(5):297-306. doi: 10.1007/BF00176893.
3
Inhibition of sympathetic hypertensive responses in the guinea-pig by prejunctional histamine H3-receptors.
豚鼠中节前组胺H3受体对交感神经高血压反应的抑制作用。
Br J Pharmacol. 1992 Oct;107(2):347-51. doi: 10.1111/j.1476-5381.1992.tb12749.x.