Physiopathologie Clinique et Expérimentale de la Schizophrénie, INSERM U666, Strasbourg, France.
Brain Cogn. 2010 Mar;72(2):255-63. doi: 10.1016/j.bandc.2009.09.009. Epub 2009 Oct 17.
Working memory is devoted to the temporary storage and on-line manipulation of information. Recently, an integrative system termed the episodic buffer has been proposed to integrate and hold information being entered or retrieved from episodic memory. Although the brain system supporting such an integrative buffer is still in debate, the medial temporal lobe appears to be a promising candidate for the maintenance of bound information. In the current work, binding was assessed by comparing two conditions in which participants had to retain three letters and three spatial locations presented either bound or separate. At the behavioral level, lower performance was found for bound information than for separate information. When contrasting the two conditions, activation in the right parahippocampal gyrus was greater for the encoding and maintenance of bound information. No activation was observed in the medial temporal lobe during the retrieval of bound information. Together, our results suggest that the parahippocampal gyrus may underlie the integrative and maintenance functions of the episodic buffer.
工作记忆专门用于临时存储和在线操作信息。最近，提出了一个综合系统，称为情景记忆缓冲区，用于整合和保存正在输入或从情景记忆中检索的信息。尽管支持这种综合缓冲区的大脑系统仍存在争议，但内侧颞叶似乎是维持绑定信息的一个有希望的候选者。在当前的工作中，通过比较两种情况来评估绑定，其中参与者必须保留三个字母和三个空间位置，这些位置要么绑定在一起，要么分开。在行为水平上，与单独的信息相比，绑定信息的表现较差。当对比两种情况时，右侧海马旁回在绑定信息的编码和维持过程中表现出更大的激活。在检索绑定信息时，没有观察到内侧颞叶的激活。总之，我们的结果表明，海马旁回可能是情景记忆缓冲区的综合和维持功能的基础。
