Van Snellenberg Jared Xavier
Department of Psychology, Columbia University, New York, NY 10027, United States.
Psychiatry Res. 2009 Nov 30;174(2):89-96. doi: 10.1016/j.pscychresns.2009.04.001. Epub 2009 Oct 17.
Patients with schizophrenia exhibit substantial deficits in both working memory (WM) and long-term memory (LTM) tasks. While these two forms of memory are generally viewed as distinct, recent evidence from healthy subjects has challenged the robustness of the double-dissociation between these two types of memory. In light of an emerging view of WM and LTM as being subserved by a largely overlapping network of brain regions, it is possible that WM and LTM deficits in patients with schizophrenia share a common neurobiological substrate. This review revisits the functional neuroimaging literature on both WM and LTM in patients with schizophrenia with these considerations in mind, and reveals a number of commonalities in research findings in both literatures. While there is a paucity of direct evidence bearing on whether patient deficits in these tasks arise from a common functional abnormality, the available literature is consistent with the hypothesis that these deficits have the same origin.
精神分裂症患者在工作记忆（WM）和长期记忆（LTM）任务中均表现出显著缺陷。虽然这两种记忆形式通常被视为截然不同，但来自健康受试者的最新证据对这两种记忆之间双重分离的稳固性提出了挑战。鉴于工作记忆和长期记忆正逐渐被视为由大量重叠的脑区网络所支持，精神分裂症患者的工作记忆和长期记忆缺陷可能具有共同的神经生物学基础。本综述在考虑到这些因素的情况下，重新审视了关于精神分裂症患者工作记忆和长期记忆的功能性神经影像学文献，并揭示了这两类文献研究结果中的一些共性。虽然缺乏关于这些任务中患者缺陷是否源于共同功能异常的直接证据，但现有文献与这些缺陷具有相同起源的假设是一致的。
