H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University Karachi, Karachi 75270, Pakistan.
Bioorg Med Chem. 2009 Nov 15;17(22):7795-801. doi: 10.1016/j.bmc.2009.09.028. Epub 2009 Sep 19.
Bis-Schiff bases 1-27 have been synthesized and their in vitro antiglycation potential has been evaluated. Compounds 21 (IC(50)=243.95+/-4.59microM), 20 (IC(50)=257.61+/-5.63microM), and 7 (IC(50)=291.14+/-2.53microM) showed an excellent antiglycation activity better than the standard (rutin, IC(50)=294.46+/-1.50microM). This study has identified a series of potential molecules as antiglycation agents. A structure-activity relationship has been studied, and all the compounds were characterized by spectroscopic techniques.
已合成了双席夫碱 1-27，并评估了它们的体外抗糖化潜力。化合物 21（IC（50）=243.95+/-4.59μM）、20（IC（50）=257.61+/-5.63μM）和 7（IC（50）=291.14+/-2.53μM）表现出优异的抗糖化活性，优于标准品（芦丁，IC（50）=294.46+/-1.50μM）。本研究已经鉴定出一系列有潜力的作为抗糖化剂的分子。已经研究了构效关系，所有化合物均通过光谱技术进行了表征。
