Coprean D, Giurgea R, Puica C, Coprean D
Biological Research Institute, Cluj-Napoca, Romania.
Rev Roum Physiol (1990). 1990 Jul-Dec;27(3-4):209-13.
A 90-day Timorom treatment of rats of both sexes modified some of the carbohydrate metabolism parameters. Some of the modifications were different in male and female rats. Glycogen storage was increased, while liver GPa activity was decreased in the male rats, but those modifications ran in the opposite direction in the female rats. In our opinion, these different reactions of male and female rats to Timorom (containing a nonselective beta-adrenergic blocking agent--timolol) depended on the different ways by which the glycogen phosphorylase system is activated. Many of the biochemical modifications, obtained after the Timorom treatment, disappeared at the end of the first post-treatment month.
对雌雄大鼠进行为期90天的噻吗洛尔治疗改变了一些碳水化合物代谢参数。其中一些改变在雄性和雌性大鼠中有所不同。雄性大鼠的糖原储备增加，而肝脏糖原磷酸化酶活性降低，但在雌性大鼠中这些改变则相反。我们认为，雄性和雌性大鼠对噻吗洛尔（含有非选择性β-肾上腺素能阻滞剂——噻吗洛尔）的这些不同反应取决于糖原磷酸化酶系统被激活的不同方式。噻吗洛尔治疗后获得的许多生化改变在治疗后的第一个月末消失。
