Straume T, Langlois R G, Lucas J, Jensen R H, Bigbee W L, Ramalho A T, Brandão-Mello C E
Environmental Division, Lawrence Livermore National Laboratory, University of California, Livermore 94550.
Health Phys. 1991 Jan;60(1):71-6. doi: 10.1097/00004032-199101000-00011.
Two biodosimetric methods under development at the Lawrence Livermore National Laboratory were applied to five persons accidentally exposed to a 137Cs source in Goiânia, Brazil. The methods used were somatic "null" mutations at the glycophorin A locus detected as missing proteins on the surface of blood erythrocytes and chromosome translocations in blood lymphocytes detected using fluorescence in-situ hybridization. Biodosimetric results obtained approximately 1 y after the accident using these new and largely unvalidated methods are in general agreement with results obtained immediately after the accident using dicentric chromosome aberrations. Additional follow-up of Goiânia accident victims will 1) help provide the information needed to validate these new methods for use in biodosimetry and 2) provide independent estimates of dose.
劳伦斯利弗莫尔国家实验室正在研发的两种生物剂量测定方法被应用于五名在巴西戈亚尼亚意外暴露于137铯源的人员。所使用的方法是通过检测血红细胞表面缺失的蛋白质来测定血型糖蛋白A位点的体细胞“零”突变，以及使用荧光原位杂交检测血液淋巴细胞中的染色体易位。使用这些新的且大多未经验证的方法在事故发生约1年后获得的生物剂量测定结果，总体上与事故发生后立即使用双着丝粒染色体畸变获得的结果一致。对戈亚尼亚事故受害者的进一步随访将：1）有助于提供验证这些用于生物剂量测定的新方法所需的信息；2）提供独立的剂量估计。
