戈亚尼亚辐射事故中受¹³⁷铯照射个体的染色体畸变情况

The fate of chromosomal aberrations in 137Cs-exposed individuals in the Goiânia radiation accident.

作者信息

Ramalho A T, Nascimento A C

机构信息

Instituto de Radioproteção e Dosimetria/CNEN, Rio de Janeiro, Brazil.

出版信息

Health Phys. 1991 Jan;60(1):67-70. doi: 10.1097/00004032-199101000-00010.

DOI:10.1097/00004032-199101000-00010

PMID:1983985

Abstract

Following the Goiânia radiation accident, lymphocytes from 110 exposed or potentially exposed individuals were analyzed for the frequencies of chromosomal aberrations (dicentrics and centric rings) to estimate absorbed radiation dose. Dose estimates for 21 subjects exceeded 1.0 Gy, and for eight subjects they exceeded 4.0 Gy. Four of the subjects died. After the emergency period, a cytogenetic follow-up of 10 of the highest exposed patients was started. The results suggest that the average disappearance half-time of lymphocytes containing dicentric and centric rings was 130 d, which is shorter than the usually accepted value of 3 y reported in the literature.

摘要

在戈亚尼亚辐射事故之后，对110名受照射或可能受照射个体的淋巴细胞进行了染色体畸变（双着丝粒和着丝粒环）频率分析，以估计吸收的辐射剂量。21名受试者的剂量估计超过1.0 Gy，8名受试者超过4.0 Gy。其中4名受试者死亡。紧急期过后，对10名受照剂量最高的患者开始了细胞遗传学随访。结果表明，含有双着丝粒和着丝粒环的淋巴细胞的平均消失半衰期为130天，这比文献报道的通常公认值3年要短。