Division of Medicine, University College London, UK.
Int J Biochem Cell Biol. 2010 Apr;42(4):486-94. doi: 10.1016/j.biocel.2009.10.012. Epub 2009 Oct 17.
Oxygen is an essential nutrient for eukaryotic life and in complex organisms a finely tuned system, based on Hypoxia Inducible Factor (HIF), has evolved to control the cellular, local and organism-wide responses to its availability. Cells of the immune system must function in a variety of local environments and it is now clear that oxygen availability is an important signal for the cells involved in immune defence. This review summarises the mechanisms by which activation of the HIF pathway influences, and is influenced by, both immune activation state and oxygen tension. It is likely that understanding how oxygen tension modulates immune function will provide insights into disease pathogenesis, and may offer new opportunities for treatment.
氧气是真核生物的必需营养素，在复杂的生物体中，基于缺氧诱导因子 (HIF) 的精细调控系统已经进化，以控制细胞、局部和整个生物体对其可用性的反应。免疫系统的细胞必须在各种局部环境中发挥作用，现在已经清楚的是，氧气供应是参与免疫防御的细胞的重要信号。这篇综述总结了 HIF 途径的激活如何影响免疫激活状态和氧气张力，以及如何受到其影响。了解氧气张力如何调节免疫功能可能有助于深入了解疾病的发病机制，并可能为治疗提供新的机会。
