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[轻度创伤性脑损伤后S100β与脑震荡后症状之间存在关联吗?]

[Is there a correlation between S100 beta and post-concussion symptoms after mild traumatic brain injury?].

作者信息

Kleinert K, Schleich F, Biasca N, Simmen H P

机构信息

Spital Oberengadin, Unfallchirurgische Klinik, CH-7503 Samedan, Schweiz.

出版信息

Zentralbl Chir. 2010 Jun;135(3):277-8. doi: 10.1055/s-0028-1098766. Epub 2009 Oct 19.

Abstract

In the past a lot of patients suffered from post-concussive symptoms (PCS) after mild traumatic brain injury (mTBI). The present prospective study (n = 73) was intended to help predict the outcome after mTBI with blood asservation for analysis of S100 beta 3 hours after trauma. There was no statistically significant correlation be-tween PCS or even of single symptoms and elevated marker levels. Serum S100 beta appears to be a poor predictor of the outcome following mild TBI. Establishing a diagnosis of "PCS" will still be hard in future, since no objective diagnostic -method exists. The most important facts are a precise examination and a history of the patient with a negative CT scan of the head.

摘要

过去,许多患者在轻度创伤性脑损伤(mTBI)后出现脑震荡后症状(PCS)。本前瞻性研究(n = 73)旨在通过创伤后3小时血液检测S100β来帮助预测mTBI后的结果。PCS甚至单个症状与标志物水平升高之间无统计学显著相关性。血清S100β似乎不是轻度TBI后结果的良好预测指标。由于不存在客观的诊断方法,未来“PCS”的诊断仍将困难。最重要的是对患者进行精确检查并结合头部CT扫描阴性的病史。

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