血清S-100B和裂解型tau蛋白对轻度创伤性脑损伤后的长期预后预测能力较差。

Serum S-100B and cleaved-tau are poor predictors of long-term outcome after mild traumatic brain injury.

作者信息

Bazarian Jeffrey J, Zemlan Frank P, Mookerjee Sohug, Stigbrand Torgney

机构信息

Department of Emergency Medicine, University of Rochester School of Medicine, Rochester, New York 14472, USA.

出版信息

Brain Inj. 2006 Jun;20(7):759-65. doi: 10.1080/02699050500488207.

PRIMARY OBJECTIVE

To determine the relationship of serum S-100B and C-tau levels to long-term outcome after mild traumatic brain injury (mild TBI).

RESEARCH DESIGN

A prospective study of 35 mild TBI subjects presenting to the emergency department.

METHODS AND PROCEDURES

Six hour serum S-100B and C-tau levels compared to 3-month Rivermead Post Concussion Questionnaire (RPCQ) scores and post-concussive syndrome (PCS).

MAIN OUTCOMES AND RESULTS

The linear correlation between marker levels and RPCQ scores was weak (S-100B: r = 0.071, C-tau: r = -0.21). There was no statistically significant correlation between marker levels and 3-month PCS (S-100B: AUC = 0.589, 95%CI. 038, 0.80; C-tau: AUC = 0.634, 95%CI 0.43, 0.84). The sensitivity of these markers ranged from 43.8-56.3% and the specificity from 35.7-71.4%.

CONCLUSIONS

Initial serum S-100B and C-tau levels appear to be poor predictors of 3-month outcome after mild TBI.

主要目标

确定血清S-100B和C-τ水平与轻度创伤性脑损伤（轻度TBI）后长期预后的关系。

研究设计

对35名到急诊科就诊的轻度TBI患者进行的前瞻性研究。

方法与步骤

将伤后6小时的血清S-100B和C-τ水平与3个月时的Rivermead脑震荡后问卷（RPCQ）评分及脑震荡后综合征（PCS）进行比较。

主要结局与结果

标志物水平与RPCQ评分之间的线性相关性较弱（S-100B：r = 0.071，C-τ：r = -0.21）。标志物水平与3个月时的PCS之间无统计学显著相关性（S-100B：AUC = 0.589，95%CI 0.38，0.80；C-τ：AUC = 0.634，95%CI 0.43，0.84）。这些标志物的敏感性为43.8 - 56.3%，特异性为35.7 - 71.4%。

结论

轻度TBI后，初始血清S-100B和C-τ水平似乎不是3个月预后的良好预测指标。