Shook B L, Villablanca J R
Department of Psychiatry and Anatomy, UCLA School of Medicine 90024.
Exp Neurol. 1991 Jan;111(1):80-94. doi: 10.1016/0014-4886(91)90053-f.
Quantitative morphometry was used to study the effects of maturationally dependent responses to brain trauma on the cytologic organization of the dorsal lateral geniculate nucleus (LGd). The left hemitelencephalon was removed in adult cats and in neonatal kittens and resultant changes in cell size and density were compared between these groups and with intact controls. Morphological changes were found bilaterally in all lesioned cats. Ipsilaterally, geniculate volume was reduced by 23% in kitten-lesioned cats and by 33% in adult-lesioned cats. The geniculate of both lesion groups contained fewer neurons in all laminae than did the nucleus of intact cats, but only the adult-lesioned cats showed a substantial increase in glial cell counts. Contralaterally, there was a tendency for a lower neuronal density in both lesion groups, but this was significant only for the A-laminae of adult-lesioned cats. Therefore, neonatal lesions spared more neurons bilaterally and produced minimal ipsilateral gliosis compared to the adult ablation. Results are discussed within the context of the "Gudden effect" which asserts that there is more retrograde degeneration in neonatal versus adult brain-lesioned animals.
采用定量形态学方法研究大脑创伤的成熟依赖性反应对背外侧膝状核（LGd）细胞组织的影响。对成年猫和新生小猫切除左侧半端脑，比较这些组与完整对照组之间细胞大小和密度的变化。在所有受损猫中双侧均发现形态学变化。同侧，小猫受损组的膝状体体积减少23%，成年受损组减少33%。与完整猫的核相比，两个损伤组的膝状体所有层中的神经元数量均较少，但只有成年受损组的神经胶质细胞计数显著增加。对侧，两个损伤组均有神经元密度降低的趋势，但仅成年受损组的A层有显著变化。因此，与成年切除相比，新生损伤双侧保留了更多神经元，同侧胶质增生也最小。研究结果在“古登效应”的背景下进行了讨论，该效应认为，与成年脑损伤动物相比，新生脑损伤动物的逆行性变性更多。
