Louis D N, Hamilton A J, Sobel R A, Ojemann R G
Department of Pathology Massachusetts General Hospital, Harvard Medical School, Boston.
J Neurosurg. 1991 Jan;74(1):129-32. doi: 10.3171/jns.1991.74.1.0129.
A sphenoid-wing meningioma in a 60-year-old woman was accompanied by elevated serum carcinoembryonic antigen (CEA) levels, which returned to normal after removal of the tumor. Light microscopic examination revealed a secretory meningioma containing numerous pseudopsammoma bodies and a prominent vascular pattern. Immunohistochemical analysis showed the tumor cells and pseudopsammoma bodies to be CEA-positive. This case illustrates the possibility that secretory meningioma may be associated with clinically detectable secretion of CEA. The report also documents the rare occurrence of elevated serum CEA in a primary benign intracranial tumor.
