Department of Surgery, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
J Sleep Res. 2010 Mar;19(1 Pt 2):192-200. doi: 10.1111/j.1365-2869.2009.00773.x. Epub 2009 Oct 21.
The gastric myoelectrical activity (GMA) fluctuates across sleep-wake states as a result of modulation by the brain-gut axis. The role of the autonomic nervous system in this phenomenon, however, was not elucidated fully. Through simultaneous recording and subsequent continuous power spectral analysis of electroencephalogram, electromyogram, electrocardiogram and electrogastromyogram (EGMG) in 16 freely moving Wistar rats, the sleep-wake states of the animals were defined and indices of cardiac autonomic regulation and GMA were calculated. We found that both cardiac autonomic regulation and GMA fluctuated through sleep-wake cycles. Correlation analysis further revealed significant correlations between EGMG power and each of the R-R interval, high-frequency power, low-frequency power, very-low-frequency power, low-frequency power to high-frequency power ratio and normalized low-frequency power of heart rate variability with respect to their trend of change across different sleep-wake states. These results suggest that the sleep-wake-related change of GMA was related to sympathovagal balance. The sympathetic nerve may play a more important role in the central modulation of GMA than perceived previously.
胃肌电活动（GMA）会随睡眠-觉醒状态而波动，这是由于脑-肠轴的调制作用。然而，自主神经系统在这一现象中的作用尚未完全阐明。通过对 16 只自由活动的 Wistar 大鼠进行脑电图、肌电图、心电图和胃电图（EGMG）的同步记录和随后的连续功率谱分析，确定了动物的睡眠-觉醒状态，并计算了心脏自主调节和 GMA 的指标。我们发现，心脏自主调节和 GMA 都随睡眠-觉醒周期而波动。相关分析进一步显示，EGMG 功率与 R-R 间期、高频功率、低频功率、极低频功率、低频功率与高频功率比以及心率变异性的归一化低频功率之间存在显著相关性，这些指标在不同的睡眠-觉醒状态下的变化趋势与 GMA 的变化趋势相对应。这些结果表明，GMA 的睡眠-觉醒相关变化与交感神经和副交感神经的平衡有关。与以往的认知相比，交感神经可能在 GMA 的中枢调节中发挥更重要的作用。
