Predicting bioavailability and bioaccumulation of arsenic by freshwater clam Corbicula fluminea using valve daily activity.

There are many bioindicators. However, it remains largely unknown which metal-bioindicator systems will give the reasonable detection ranges of bioavailable metals in the aquatic ecosystem. Various experimental data make the demonstration of biomonitoring processes challenging. Ingested inorganic arsenic is strongly associated with a wide spectrum of adverse health outcomes. Freshwater clam Corbicula fluminea, one of the most commonly used freshwater biomomitoring organisms, presents daily activity in valve movement and demonstrates biotic uptake potential to accumulate arsenic. Here, a systematical way was provided to dynamically link valve daily activity in C. fluminea and arsenic bioavailability and toxicokinetics to predict affinity at arsenic-binding site in gills and arsenic body burden. Using computational ecotoxicology methods, a valve daily rhythm model can be tuned mathematically to the responsive ranges of valve daily activity system in response to varied bioavailable arsenic concentration. The patterned response then can be used to predict the site-specific bioavailable arsenic concentration at the specific measuring time window. This approach can yield predictive data of results from toxicity studies of specific bioindicators that can assist in prediction of risk for aquatic animals and humans.