Wang Shao-Jie, Jiao Cheng-Yuan, Sun Xiao-Di
Department of Chinese Medicine, Dalian Children's Hospital, Liaoning.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Aug;29(8):742-5.
To investigate the effect of Jiawei Yupingfeng Mixture (YPF) on repeated respiratory tract infection (RRTI) and its impacts on T-cell subsets, immunoglobulin and erythrocyte immune.
Two hundred children with RRTI were assigned equally to two groups, the test group treated with YPF and the control group treated by transfer factor. The clinical efficacy, and the changes of T-cell subsets, immunoglobulin and erythrocyte immune before and after treatment were observed in 31 patients randomly selected from each group.
After treatment, the frequency of attacking was reduced and the course of attacking was shortened significantly in the test group as compared with before treatment and also with the control group (P < 0.01); IgG and IgA levels were improved in both groups, but the improvement was more significant in the test group (P<0.01, P<0.05); T-cell subsets indices, including CD3(+), CD4(+), CD8(+) and CD4(+)/CD8(+) ratio, all improved in the test group significantly (P <0.01), while in the control group, significant improvement only showed in rising of CD3(+) and CD4(+) (P <0.05, P <0.01), comparison between groups showed significant difference in terms of CD3(+), CD4(+) and CD8(+); in the control group, levels of C3b, RFER and RFIR were changed significantly (P<0.05, P<0.01), but the improvement of ICR was insignificant, while in the test group, the above indices were significant improved as compared with after treatment of the control group (P <0.01).
YPF plays a preventive and therapeutic role in children with RRTI by way of regulating the cellular and humoral immune.
探讨加味玉屏风合剂（YPF）对反复呼吸道感染（RRTI）的影响及其对T细胞亚群、免疫球蛋白和红细胞免疫的作用。
将200例RRTI患儿平均分为两组，试验组给予YPF治疗，对照组给予转移因子治疗。从每组中随机选取31例患者，观察治疗前后的临床疗效、T细胞亚群、免疫球蛋白和红细胞免疫的变化。
治疗后，试验组发作频率降低，发作病程明显缩短，与治疗前及对照组相比差异均有统计学意义（P<0.01）；两组IgG和IgA水平均有所提高，但试验组改善更显著（P<0.01，P<0.05）；试验组T细胞亚群指标，包括CD3(+)、CD4(+)、CD8(+)及CD4(+)/CD8(+)比值均显著改善（P<0.01），而对照组仅CD3(+)和CD4(+)升高有显著改善（P<0.05，P<0.01），组间比较CD3(+)、CD4(+)和CD8(+)差异有统计学意义；对照组C3b、RFER和RFIR水平变化显著（P<0.05，P<0.01），但ICR改善不明显，而试验组上述指标与对照组治疗后相比改善显著（P<0.01）。
YPF通过调节细胞免疫和体液免疫对RRTI患儿起到防治作用。
