Alvarez D, Mastai R, Lennie A, Soifer G, Levi D, Terg R
Hospital Nacional de Gastroenterologia Dr. C.B. Udaondo, Buenos Aires, Argentina.
Dig Dis Sci. 1991 Jan;36(1):82-6. doi: 10.1007/BF01300092.
The present study aims to evaluate the usefulness of combined pulse Doppler-real-time ultrasonography as a noninvasive method for the measurement of portal blood flow in man. This measurement technique was performed on 12 healthy subjects and 20 patients with portal hypertension. Ten patients (group 1) were evaluated prior to and after ingestion of a standard meal (Ensure Plus) or placebo. In the remaining 10 patients (group 2), the effects of isosorbide dinitrate (5 mg/SL) administration or placebo were studied. In group 1, food intake caused a significant increase of portal blood flow (from 1038 +/- 539 to 1572 +/- 759 ml/min, P less than 0.02); this effect was due to a significant rise in mean blood velocity (from 18.5 +/- 3.7 to 23.9 +/- 3.9 cm/sec, P less than 0.02). In group 2, isosorbide dinitrate significantly reduced portal blood flow (from 985 +/- 491 to 625 +/- 355 ml/min, P less than 0.05); a significant decline of mean blood velocity (from 18.8 +/- 4.5 to 14.5 +/- 2.5 cm/sec, P less than 0.02) was observed. Placebo administration had no significant hemodynamic effects in either group. Our results suggest that Doppler measurements gave accurate noninvasive estimations of portal blood flow and that this technique may be used to monitor physiological and pharmological stimuli in patients with portal hypertension.
本研究旨在评估联合脉冲多普勒 - 实时超声检查作为一种无创测量人体门静脉血流方法的实用性。该测量技术应用于12名健康受试者和20名门静脉高压患者。10名患者（第1组）在摄入标准餐（安素益力佳）或安慰剂前后接受评估。其余10名患者（第2组）研究了服用硝酸异山梨酯（5mg/舌下含服）或安慰剂的效果。在第1组中，进食导致门静脉血流显著增加（从1038±539增至1572±759ml/分钟，P＜0.02）；这种效应是由于平均血流速度显著升高（从18.5±3.7增至23.9±3.9cm/秒，P＜0.02）。在第2组中，硝酸异山梨酯显著降低门静脉血流（从985±491降至625±355ml/分钟，P＜0.05）；观察到平均血流速度显著下降（从18.8±4.5降至14.5±2.5cm/秒，P＜0.02）。服用安慰剂在两组中均未产生显著的血流动力学效应。我们的结果表明，多普勒测量能够准确无创地估计门静脉血流，并且该技术可用于监测门静脉高压患者的生理和药理刺激。
