Norwegian School of Veterinary Science, Department of Production Animal Clinical Sciences, Oslo, Norway.
Toxicol Lett. 2010 Feb 1;192(2):126-33. doi: 10.1016/j.toxlet.2009.10.008. Epub 2009 Oct 20.
The aim of the present study was to investigate whether low levels of mono-ortho PCB 118 and di-ortho PCB 153, affect bone composition and strength in ewes (Dala breed) and their foetuses following exposure starting at conception and ending a week before expected delivery. In male foetuses, trabecular bone mineral content at the metaphysis was almost 30% lower in the PCB 118 (49 microg/kg body wt/day) group compared to the control group (corn oil) (ANCOVA, P<0.05). In female foetuses of the PCB 153 (98 microg/kg body wt/day) group trabecular cross-sectional area at the metaphysis was 19% smaller than in the controls (ANCOVA, P<0.05). At the diaphysis a smaller marrow cavity area (up to 24% reduction) was observed in female and male foetuses exposed to PCB 153 compared with controls (ANCOVA, P<0.05). There were also significant differences at the mid diaphyseal measure point between the PCB 153 and the control group females (ANCOVA, P<0.05). Cortical and total bone mineral density, cortical thickness were significantly higher, endosteal circumference shorter and marrow cavity significantly smaller in the PCB 153 group (ANCOVA, P<0.05). In conclusion there were gender dependent effects on bone tissue and cortical bone was more affected than trabecular bone.
本研究旨在探讨低水平的单-邻位多氯联苯 118 和双-邻位多氯联苯 153 是否会影响怀孕初期开始暴露并在预计分娩前一周结束的母羊（达拉品种）及其胎儿的骨组成和强度。在雄性胎儿中，与对照组（玉米油）相比，118 组（49μg/kg 体重/天）的骺骨小梁骨矿物质含量降低了近 30%（ANCOVA，P<0.05）。在 153 组（98μg/kg 体重/天）的雌性胎儿中，骺骨小梁的横截面积比对照组小 19%（ANCOVA，P<0.05）。与对照组相比，暴露于 153 的雌性和雄性胎儿的骨干骨髓腔面积更小（最大减少 24%）（ANCOVA，P<0.05）。在 153 组和对照组女性的骨干中部测量点之间也存在显著差异（ANCOVA，P<0.05）。153 组的皮质和总骨矿物质密度、皮质厚度显著升高，骨髓腔显著减小，而骨内表面周长和骨干腔显著减小（ANCOVA，P<0.05）。总之，骨组织存在性别依赖性影响，皮质骨比小梁骨更容易受到影响。
