Department of Dermatology, California Pacific Medical Center, San Francisco, CA, USA.
Dermatol Clin. 2009 Oct;27(4):473-8, vi. doi: 10.1016/j.det.2009.08.012.
Nonablative fractional resurfacing (NFR) uses a mode of delivery with preservation of the stratum corneum, a true resurfacing with epidermal extrusion, and creation of microscopic thermal zones of injury that ultimately lead to neocollagenesis. This article discussed the science, clinical indications, patient selection and preparation, posttreatment care, and complications of NFR. It concludes that the most impressive clinical results are seen with acne scars, surgical and traumatic scars, and mild to moderate facial and nonfacial dyschromia or photoaging. Modest results can be seen with therapy-resistant melasma and certain types of rhytides. Future approaches include synergistic treatments with radiofrequency devices and the development of novel wavelengths to enhance the efficacy of NFR while preserving safety.
非剥脱性分段式换肤术（NFR）采用一种保留角质层的传递模式，实现真正的表皮挤出式换肤，并产生微小的热损伤区域，最终导致新胶原形成。本文讨论了 NFR 的科学基础、临床适应证、患者选择和准备、治疗后护理以及并发症。结论是，NFR 在治疗痤疮疤痕、手术和创伤疤痕以及轻度至中度面部和非面部色素沉着或光老化方面效果最显著。对于治疗抵抗性黄褐斑和某些类型的皱纹，也可以看到适度的效果。未来的方法包括与射频设备的协同治疗以及开发新型波长以提高 NFR 的疗效同时保持安全性。
