Holcomb John David
Holcomb - Kreithen Plastic Surgery and Medspa, Sarasota, FL, USA.
J Cosmet Dermatol. 2021 Jun;20(6):1668-1678. doi: 10.1111/jocd.14106. Epub 2021 Apr 7.
Effects of low energy, single-pass helium plasma dermal resurfacing (PDR) treatment on brown spots, enlarged pores, and wrinkles-preliminary findings.
Twenty two subjects (64.6 ± 6.6 years) with Fitzpatrick Wrinkle and Elastosis Scale score (FWS) of ≤2 and seeking improvement of facial appearance were included in this subanalysis. All subjects received a single, one-pass, full face, and low power helium PDR treatment. Standard digital images were collected using the VISIA-CR (Canfield Scientific Inc.) at baseline and 3 months after treatment with images assessed for improvement in FWS and for improvements in brown spots, enlarged pores, and wrinkles by proprietary automated image processing algorithms.
Nearly all subjects demonstrated ≥1-point improvement in FWS and also reported improvement per modified Global Aesthetic Improvement Scale query. The numbers of brown spots and enlarged pores decreased by 45.1% and 28.3%, respectively. Stratification of brown spots data by presence or absence of post-inflammatory hyperpigmentation revealed paradoxically conflicting data. The improvement detected in wrinkle area and mean wrinkle thickness was less pronounced with overall reductions of 13.4% and 4.8%, respectively. 37 Non-serious adverse events (AEs) in 22 subjects were reported with most resolving within 14 days or less, and no serious AEs were observed.
While longer-term follow-up is needed, these early study results show that one single-pass, low energy helium PDR treatment improves facial skin appearance both qualitatively and quantitatively. Studies evaluating higher energy levels and multiple treatment passes are ongoing.
低能量单次通过氦等离子体皮肤重建术(PDR)治疗对褐斑、毛孔粗大和皱纹的影响——初步研究结果。
本亚组分析纳入了22名受试者(64.6±6.6岁),其菲茨帕特里克皱纹和弹性组织量表评分(FWS)≤2,且寻求改善面部外观。所有受试者均接受了单次、单通道、全脸低功率氦PDR治疗。在基线和治疗后3个月使用VISIA-CR(Canfield Scientific Inc.)收集标准数字图像,并通过专有的自动图像处理算法评估图像在FWS、褐斑、毛孔粗大和皱纹方面的改善情况。
几乎所有受试者的FWS均有≥1分的改善,并且根据改良的全球美学改善量表查询结果也报告有改善。褐斑和毛孔粗大的数量分别减少了45.1%和28.3%。根据是否存在炎症后色素沉着对褐斑数据进行分层,结果显示出相互矛盾的数据。在皱纹面积和平均皱纹厚度方面检测到的改善不太明显,总体减少分别为13.4%和4.8%。报告了22名受试者出现37例非严重不良事件(AE),大多数在14天或更短时间内消退,未观察到严重AE。
虽然需要进行长期随访,但这些早期研究结果表明,单次通过的低能量氦PDR治疗在定性和定量方面均能改善面部皮肤外观。评估更高能量水平和多次治疗的研究正在进行中。