Guthrie E, Creed F, Dawson D, Tomenson B
Department of Psychiatry, Manchester Royal Infirmary, England.
Gastroenterology. 1991 Feb;100(2):450-7. doi: 10.1016/0016-5085(91)90215-7.
One hundred two patients with irritable bowel syndrome were studied in a controlled trial of psychological treatment involving psychotherapy, relaxation, and standard medical treatment compared with standard medical treatment alone. Patients were only selected if their symptoms had not improved with standard medical treatment over the previous 6 months. At 3 months, the treatment group showed significantly greater improvement than the controls on both gastroenterologists' and patients' ratings of diarrhea and abdominal pain, but constipation changed little. Good prognostic factors included overt psychiatric symptoms and intermittent pain exacerbated by stress, whereas those with constant abdominal pain were helped little by this treatment. This study has demonstrated that psychological treatment is feasible and effective in two thirds of those patients with irritable bowel syndrome who do not respond to standard medical treatment.
在一项关于心理治疗的对照试验中，对102例肠易激综合征患者进行了研究。该心理治疗包括心理疗法、放松训练以及与单纯标准药物治疗相对比的标准药物治疗。仅当患者在过去6个月中接受标准药物治疗后症状未改善时才被选入研究。3个月时，在胃肠病学家和患者对腹泻及腹痛的评分方面，治疗组的改善程度显著大于对照组，但便秘情况变化不大。良好的预后因素包括明显的精神症状以及由压力加剧的间歇性疼痛，而持续性腹痛患者接受这种治疗后获益甚微。这项研究表明，对于三分之二对标准药物治疗无反应的肠易激综合征患者，心理治疗是可行且有效的。
