顺铂耳毒性及其防护：临床与实验研究。
Cisplatin ototoxicity and protection: clinical and experimental studies.
机构信息
Department of Surgery, Southern Illinois University School of Medicine, IL, USA.
出版信息
Tohoku J Exp Med. 2009 Nov;219(3):177-86. doi: 10.1620/tjem.219.177.
Abstract
Cisplatin is a chemotherapeutic agent that is widely used to treat a variety of malignant tumors. Serious dose-limiting side effects like ototoxicity, nephrotoxicity and neurotoxicity occur with the use of this agent. This review summarizes recent important clinical and experimental investigations of cisplatin ototoxicity. It also discusses the utility of protective agents employed in patients and in experimental animals. The future strategies for limiting cisplatin ototoxicity will need to avoid interference with the therapeutic effect of cisplatin in order to enhance the quality of life of patients receiving this important anti-tumor agent.
摘要
顺铂是一种广泛用于治疗多种恶性肿瘤的化疗药物。在使用该药物时，会出现严重的剂量限制副作用，如耳毒性、肾毒性和神经毒性。本文综述了最近关于顺铂耳毒性的重要临床和实验研究。还讨论了在患者和实验动物中使用的保护剂的效用。限制顺铂耳毒性的未来策略需要避免干扰顺铂的治疗效果，以提高接受这种重要抗肿瘤药物治疗的患者的生活质量。
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