Jiménez-Bonilla Julio F, Quirce Remedios, Banzo Ignacio, Martínez-Rodríguez Isabel, Sainz-Esteban Aurora, Portilla Humberto, Carril José Manuel
Department of Nuclear Medicine, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Santander, Cantabria, España.
Clin Nucl Med. 2009 Nov;34(11):768-72. doi: 10.1097/RLU.0b013e3181b7d757.
To evaluate the relationship between temporal hypoperfusion in the acute phase of patients with eating disorders and the long-term clinical outcome.
Brain perfusion was studied using Tc-99m HMPAO SPECT in 17 patients with eating disorders (ED) and compared with 12 controls (C). Semiquantitative analysis was carried out by left/right indexes. Clinical records were reviewed 15 years later and the patients were classified into 2 groups: bad outcome in 10 patients and good outcome in 4. The results of the basal SPECT were compared with the clinical outcome.
The mean of the differences of temporal perfusion in the lower slice was 0.1476 +/- 0.1121 in ED and 0.03 +/- 0.019 in C (P < 0.001). Comparisons between C and bad outcome showed a significant difference (P < 0.01). There was no significant difference between good outcome and C.
The temporal hypoperfusion in the acute phase of patients with ED showed a correlation with the long-term clinical outcome and suggested a prognostic value of temporal hypoperfusion.
评估饮食失调患者急性期颞叶灌注不足与长期临床结局之间的关系。
对17例饮食失调（ED）患者使用锝-99m六甲基丙烯胺肟单光子发射计算机断层扫描（Tc-99m HMPAO SPECT）研究脑灌注，并与12名对照者（C）进行比较。通过左右指数进行半定量分析。15年后复查临床记录，将患者分为两组：10例预后不良，4例预后良好。将基础SPECT结果与临床结局进行比较。
ED组下部层面颞叶灌注差异的平均值为0.1476±0.1121，C组为0.03±0.019（P<0.001）。C组与预后不良组之间的比较显示出显著差异（P<0.01）。预后良好组与C组之间无显著差异。
ED患者急性期的颞叶灌注不足与长期临床结局相关，提示颞叶灌注不足具有预后价值。
