Bracken Adrian P, Helin Kristian
The Smurfit Institute of Genetics, Trinity College Dublin and The Adelaide & Meath Hospital, including the National Children's Hospital, Dublin, Ireland.
Nat Rev Cancer. 2009 Nov;9(11):773-84. doi: 10.1038/nrc2736.
The Polycomb group (PcG) proteins are transcriptional repressors that regulate lineage choices during development and differentiation. Recent studies have advanced our understanding of how the PcG proteins regulate cell fate decisions and how their deregulation potentially contributes to cancer. In this Review we discuss the emerging roles of long non-coding RNAs (ncRNAs) and a subset of transcription factors, which we call cell fate transcription factors, in the regulation of PcG association with target genes. We also speculate about how their deregulation contributes to tumorigenesis.
多梳蛋白家族（PcG）是一类转录抑制因子，在发育和分化过程中调节细胞谱系选择。最近的研究增进了我们对PcG蛋白如何调控细胞命运决定以及其失调如何可能导致癌症的理解。在本综述中，我们讨论了长链非编码RNA（ncRNA）和一类转录因子（我们称之为细胞命运转录因子）在调控PcG与靶基因结合方面的新作用。我们还推测了它们的失调如何促进肿瘤发生。
