“派对药丸”药物 N-苄基哌嗪（BZP）在健康人体受试者中的药代动力学。
Pharmacokinetics of 'party pill' drug N-benzylpiperazine (BZP) in healthy human participants.
作者信息
Antia U, Lee H S, Kydd R R, Tingle M D, Russell B R
机构信息
School of Pharmacy, University of Auckland, Private Bag 92019, Auckland, New Zealand.
出版信息
Forensic Sci Int. 2009 Apr 15;186(1-3):63-7. doi: 10.1016/j.forsciint.2009.01.015. Epub 2009 Mar 3.
There have been many reports of benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP) being used as recreational drugs which have been widely marketed in the form of 'party pills' since the late 1990's. However, there is no information currently available describing the pharmacokinetics of these drugs in humans. Human plasma concentrations of BZP were measured in blood and urine samples taken from healthy adults (n=7) over 24h following a 200mg oral dose of BZP. Plasma concentrations of BZP were found to peak at 262 ng/mL (C(max)) and 75min (T(max)). Plasma concentrations of the major metabolites of BZP, 4-OH BZP and 3-OH BZP, were found to peak at 7 ng/mL (at 60 min) and 13 ng/mL (at 75 min) respectively. The elimination half-life (t(1/2)) for BZP was found to be 5.5h. Clearance (Cl/F) was found to be 99L/h. The results of this study indicate that BZP may be detectable in plasma for up to 30 h following an oral dose. Additionally, several urinary metabolites can be detected.
自20世纪90年代末以来，有许多关于苄基哌嗪（BZP）和三氟甲基苯基哌嗪（TFMPP）被用作消遣性药物的报道，这些药物以“派对药丸”的形式被广泛销售。然而，目前尚无关于这些药物在人体中药代动力学的信息。在20名健康成年人（n = 7）口服200mg BZP后的24小时内，对采集的血液和尿液样本中的人体血浆BZP浓度进行了测量。发现BZP的血浆浓度在262 ng/mL（C(max)）时达到峰值，时间为75分钟（T(max)）。发现BZP的主要代谢产物4-OH BZP和3-OH BZP的血浆浓度分别在7 ng/mL（60分钟时）和13 ng/mL（75分钟时）达到峰值。发现BZP的消除半衰期（t(1/2)）为5.5小时。清除率（Cl/F）为99L/h。该研究结果表明，口服一剂BZP后，血浆中BZP的可检测时间可能长达30小时。此外，还可检测到几种尿液代谢产物。
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