Pfohl B, Rederer M, Coryell W, Stangl D
Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242.
J Nerv Ment Dis. 1991 Jan;179(1):44-7. doi: 10.1097/00005053-199101000-00009.
We examined the clinical data for 230 depressed inpatients who had completed a dexamethasone suppression test (DST) to determine whether those with an elevated post-DST serum cortisol level exhibited any of the classic physiological stigmata of Cushing's syndrome. Hypertension was significantly more frequent among DST nonsuppressors (21.2%) than among normal suppressors (11.3%). Percent blood lymphocyte count was significantly lower among nonsuppressors. Confounders such as gender, age, body weight, and use of antihypertensives did not account for the findings. Implications for morbidity and mortality rates among patients with affective disorder are discussed.
我们检查了230名完成地塞米松抑制试验（DST）的住院抑郁症患者的临床资料，以确定DST后血清皮质醇水平升高的患者是否表现出任何库欣综合征的典型生理特征。DST无抑制者（21.2%）的高血压发生率显著高于正常抑制者（11.3%）。无抑制者的血液淋巴细胞百分比显著更低。性别、年龄、体重和使用抗高血压药物等混杂因素并不能解释这些结果。文中讨论了这些结果对情感障碍患者发病率和死亡率的影响。
