Pfohl B, Coryell W, Stangl D, Zimmerman M
Biol Psychiatry. 1986 Aug;21(10):931-8. doi: 10.1016/0006-3223(86)90267-2.
We examined the association between post-dexamethasone suppression test (DST) serum cortisol and body weight, self-report of weight loss during the episode, and measured weight loss during the first week of admission in a series of 245 depressed inpatients. Data on measured weight loss between two successive admissions was available in a group of 57 depressed inpatients. Reported weight loss during the episode and measured weight loss during the first week of admission were not related to DST nonsuppression. In contrast, DST nonsuppression was significantly more frequent in patients with measured weight loss between two successive admissions. This association was particularly strong in patients with below-average body weight and was practically nonexistent in patients with above-average body weight. Multivariate analysis indicates that a significant association between DST results and weight loss may be missed if self-report is substituted for direct measurement of weight loss and if potential confounders, such as total body weight, age, and sex, are ignored.
我们在245名抑郁住院患者中，研究了地塞米松抑制试验（DST）后血清皮质醇与体重、发作期间体重减轻的自我报告以及入院第一周测量的体重减轻之间的关联。在一组57名抑郁住院患者中，可获得两次连续入院期间测量的体重减轻数据。发作期间报告的体重减轻和入院第一周测量的体重减轻与DST未被抑制无关。相比之下，在两次连续入院期间测量体重减轻的患者中，DST未被抑制的情况明显更频繁。这种关联在体重低于平均水平的患者中尤为强烈，而在体重高于平均水平的患者中几乎不存在。多变量分析表明，如果用自我报告代替体重减轻的直接测量，并且忽略诸如总体重、年龄和性别等潜在混杂因素，可能会遗漏DST结果与体重减轻之间的显著关联。
