Kronfol Z, Nasrallah H A, Chapman S, House J D
J Affect Disord. 1985 Sep;9(2):169-73. doi: 10.1016/0165-0327(85)90097-7.
Depression is often associated with hypercortisolemia. Because high levels of cortisol influence the distribution of different types of leukocytes in the blood stream, we examined the percentages and absolute numbers of circulating neutrophils and lymphocytes in 29 depressed patients who were nonsuppressors on the Dexamethasone Suppression Test (DST), 28 depressed patients who were suppressors on the DST, and 52 schizophrenic controls. We found no significant differences in either RBC or WBC counts in the 3 groups. There were, however, significant differences in the percentages of both neutrophils and lymphocytes as well as the absolute number of lymphocytes among the groups. These differences were mostly due to significantly lower lymphocyte percentages and absolute counts in the depression-nonsuppressor group. We also found a significant negative association between post-dexamethasone plasma cortisol concentrations and blood lymphocyte counts. These data suggest a close interaction between cortisol metabolism and lymphocyte regulation in major depression.
抑郁症常与高皮质醇血症相关。由于高水平的皮质醇会影响不同类型白细胞在血流中的分布，我们检测了29名地塞米松抑制试验（DST）无抑制反应的抑郁症患者、28名DST有抑制反应的抑郁症患者以及52名精神分裂症对照者循环中性粒细胞和淋巴细胞的百分比及绝对数量。我们发现三组的红细胞计数或白细胞计数均无显著差异。然而，三组之间中性粒细胞和淋巴细胞的百分比以及淋巴细胞的绝对数量存在显著差异。这些差异主要是由于抑郁症无抑制反应组的淋巴细胞百分比和绝对计数显著降低。我们还发现地塞米松给药后血浆皮质醇浓度与血液淋巴细胞计数之间存在显著的负相关。这些数据表明在重度抑郁症中皮质醇代谢与淋巴细胞调节之间存在密切的相互作用。
