1800MHz GSM 类信号对非妊娠、妊娠和新生兔肝脏氧化 DNA 和脂质损伤的影响。

The influence of 1800 MHz GSM-like signals on hepatic oxidative DNA and lipid damage in nonpregnant, pregnant, and newly born rabbits.

机构信息

Department of Biophysics, Gazi University, Faculty of Medicine, Gazi Universitesi Tip Fakültesi Biyofizik Abd, Dekanlik Binasi 5. Kat, 06500, Besevler, Ankara, Turkey.

出版信息

Cell Biochem Biophys. 2010;56(1):39-47. doi: 10.1007/s12013-009-9068-1.

DOI:10.1007/s12013-009-9068-1

PMID:19851891

Abstract

The aim of our study is to evaluate the possible biological effects of whole-body 1800 MHz GSM-like radiofrequency (RF) radiation exposure on liver oxidative DNA damage and lipid peroxidation levels in nonpregnant, pregnant New Zealand White rabbits, and in their newly borns. Eighteen nonpregnant and pregnant rabbits were used and randomly divided into four groups which were composed of nine rabbits: (i) Group I (nonpregnant control), (ii) Group II (nonpregnant-RF exposed), (iii) Group III (pregnant control), (iv) Group IV (pregnant-RF exposed). Newborns of the pregnant rabbits were also divided into two groups: (v) Group V (newborns of Group III) and (vi) Group VI (newborns of Group III). 1800 MHz GSM-like RF radiation whole-body exposure (15 min/day for a week) was applied to Group II and Group IV. No significant differences were found in liver 8 OHdG/10(6) dG levels of exposure groups (Group II and Group IV) compared to controls (Group I and Group III). However, in Group II and Group IV malondialdehyde (MDA) and ferrous oxidation in xylenol orange (FOX) levels were increased compared to Group I (P < 0.05, Mann-Whitney). No significant differences were found in liver tissue of 8 OHdG/10(6) dG and MDA levels between Group VI and Group V (P > 0.05, Mann-Whitney) while liver FOX levels were found significantly increased in Group VI with respect to Group V (P < 0.05, Mann-Whitney). Consequently, the whole-body 1800 MHz GSM-like RF radiation exposure may lead to oxidative destruction as being indicators of subsequent reactions that occur to form oxygen toxicity in tissues.

摘要

本研究旨在评估全身 1800MHz GSM 样射频（RF）辐射暴露对非妊娠、妊娠新西兰白兔及其新生仔肝脏氧化 DNA 损伤和脂质过氧化水平的可能生物学影响。使用了 18 只非妊娠和妊娠兔，并将其随机分为四组，每组 9 只兔：（i）组 I（非妊娠对照组），（ii）组 II（非妊娠 RF 暴露组），（iii）组 III（妊娠对照组），（iv）组 IV（妊娠 RF 暴露组）。妊娠兔的新生仔也分为两组：（v）组 V（组 III 的新生仔）和（vi）组 VI（组 III 的新生仔）。对组 II 和组 IV 进行 1800MHz GSM 样 RF 全身辐射暴露（每周 15 分钟，共 7 天）。与对照组（组 I 和组 III）相比，暴露组（组 II 和组 IV）的肝脏 8-OHdG/10（6）dG 水平无显著差异。然而，与组 I 相比，组 II 和组 IV 的丙二醛（MDA）和二甲苯酚橙铁氧化（FOX）水平升高（P<0.05，Mann-Whitney）。组 VI 和组 V 之间肝脏组织 8-OHdG/10（6）dG 和 MDA 水平无显著差异（P>0.05，Mann-Whitney），而组 VI 的肝脏 FOX 水平与组 V 相比显著升高（P<0.05，Mann-Whitney）。因此，全身 1800MHz GSM 样 RF 辐射暴露可能导致氧化破坏，作为随后发生在组织中形成氧毒性的反应指标。