Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA.
Am J Ind Med. 2009 Dec;52(12):909-15. doi: 10.1002/ajim.20764.
Accelerated loss of forced expiratory volume in 1 s (FEV(1)) in an individual is considered an indicator of developing lung disease.
We investigated longitudinal FEV(1) slopes, calculated by simple linear regression, and adverse health outcomes after 10-30 years, among 1,428 chemical plant workers. Cases were defined by FEV(1) slopes below 5th percentile values for the cohort. Cases were matched with controls (107 pairs) for race, gender, smoking status, year of birth, age, height, and calendar year at first test. Matched pair statistics were used for comparisons.
Cases had a higher proportion, compared to controls, of diagnosis of COPD or emphysema (17.8% vs. 1.9%, P = 0.0002), medication use for respiratory diseases (24.3% vs. 4.7%, P < 0.0001), dyspnea (15% vs. 3.7%, P = 0.0042), and wheezing or rhonchi on examination (10.3% vs. 1.9%, P = 0.0225).
Chemical plant workers who experienced accelerated FEV(1) declines experienced four to nine times as many adverse health conditions over 10-30 years.
个体用力呼气量 1 秒（FEV1）的加速损失被认为是肺部疾病发展的指标。
我们研究了 1428 名化工厂工人的纵向 FEV1 斜率，通过简单线性回归计算，并在 10-30 年后调查了不良健康结果。病例通过 FEV1 斜率低于队列第 5 百分位值来定义。病例与对照组（107 对）按种族、性别、吸烟状况、出生年份、年龄、身高和首次测试的日历年份进行匹配。使用匹配对统计数据进行比较。
与对照组相比，病例组中 COPD 或肺气肿的诊断比例更高（17.8%对 1.9%，P = 0.0002），用于治疗呼吸系统疾病的药物使用比例更高（24.3%对 4.7%，P<0.0001），呼吸困难的比例更高（15%对 3.7%，P = 0.0042），检查时出现喘息或喘鸣的比例更高（10.3%对 1.9%，P = 0.0225）。
经历 FEV1 加速下降的化工厂工人在 10-30 年内经历了四到九倍的不良健康状况。
