解读纵向肺功能：体重增加和其他影响识别过度 FEV1 下降的因素。

Interpreting longitudinal spirometry: weight gain and other factors affecting the recognition of excessive FEV1 decline.

机构信息

Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA.

出版信息

Am J Ind Med. 2009 Oct;52(10):782-9. doi: 10.1002/ajim.20727.

DOI:10.1002/ajim.20727

PMID:19670262

Abstract

BACKGROUND

Excessive FEV(1) loss in an individual or a group can reflect hazardous exposures and development of lung disease. However, multiple factors may affect FEV(1) measurements.

METHODS

Using medical screening data collected in 1884 chemical plant workers between 1973 and 2003, the influence of multiple factors on repeated measurements of FEV(1) was examined.

RESULTS

The FEV(1) level was associated with age, height, race, sex, cigarette smoking, changes in body weight, and spirometer model. After controlling for these factors, longitudinal FEV(1) decline averaged 23.8 ml/year for white males; an additional loss of 8.3 ml was associated with one pack-year smoking and 5.4 ml with a one pound weight gain. Depending on the spirometer model, FEV(1) differed by up to 95 ml.

CONCLUSIONS

The study results provide quantitative estimates of the effect of specific factors on FEV(1), and should be useful to health professionals in the evaluation of accelerated lung function declines.

摘要

背景

个体或群体中过度的 FEV(1)损失可反映出有害暴露和肺部疾病的发展。然而，多种因素可能会影响 FEV(1)的测量。

方法

利用 1973 年至 2003 年间在 1884 名化工厂工人中收集的医学筛查数据，研究了多种因素对 FEV(1)重复测量的影响。

结果

FEV(1)水平与年龄、身高、种族、性别、吸烟状况、体重变化和肺活量计型号有关。在控制了这些因素后，白人男性的纵向 FEV(1)下降平均为每年 23.8 毫升；每包年吸烟量会导致 FEV(1)额外损失 8.3 毫升，每磅体重增加会导致 FEV(1)损失 5.4 毫升。根据肺活量计型号的不同，FEV(1)的差异最大可达 95 毫升。