Osman Yisilayin, Gu Deng-An, Zuo Xin-Ping, Lan Qin-Xian, Zhou Xiao-Jun, Tong Su-Xiang, Li Xiong, Zhang Yi, Jumahun Ruziguli, Chen Wei, Zhao Wei-Qing, Li Jian-Fa, Yin Yan-Ju
Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region, Urnmqi 830002, China.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2009 Jun;27(3):237-40.
To investigate the epidemiological status of visceral leishmaniasis in Hamangou coal mine area of Korla City of Xinjiang Uygur Autonomous Region.
Based on a hint of possible existence of patients, a retrospective survey was carried out house by house to find cases with suspected signs/symptoms of the disease. Meanwhile, a survey on current status was conducted, including physical examination (liver and spleen palpation) to those less than 15 years-old, leishmanin skin test and rk39 immunochromatographic strip test for part of the residents. Bone marrow smears were examined for the cases with clinical signs/symptoms and positive rk39 strip test. Sandflies were collected using routine methods in and around the area, identified, and dissected to find infection of promastigotes.
Leishmanin skin test was performed in 185 people with a positive rate of 21.1% (39/185), 39 out of 140 local residents who have lived there for more than 6 years showed positive (27.9%), while all residents who have lived less than 6 years and children under 5 years old were negative. Of the 81 children under 15 years old with a negative skin test, one showed positive for rk39 strip test, and leishmania body was found in the bone marrow smear of this case, so confirmed as visceral leishmaniasis. 12 sandflies were identified as Phlebotomus alexandri, and natural infection with promastigotes was found in one sandly.
The investigation confirms that visceral leishmaniasis is endemic in the Hamangou coal mine area.
调查新疆维吾尔自治区库尔勒市哈满沟煤矿区内脏利什曼病的流行状况。
基于可能存在患者的线索，逐户进行回顾性调查以发现有该疾病疑似体征/症状的病例。同时，开展现况调查，包括对15岁以下人群进行体格检查（触诊肝脏和脾脏），对部分居民进行利什曼原虫皮肤试验和rk39免疫层析试纸条检测。对有临床体征/症状且rk39试纸条检测呈阳性的病例进行骨髓涂片检查。采用常规方法在该区域内及周边采集白蛉，进行鉴定并解剖以查找前鞭毛体感染情况。
对185人进行了利什曼原虫皮肤试验，阳性率为21.1%（39/185），140名在当地居住超过6年的当地居民中有39人呈阳性（27.9%），而所有居住时间不足6年的居民和5岁以下儿童均为阴性。在81名皮肤试验阴性的15岁以下儿童中，1人rk39试纸条检测呈阳性，该病例骨髓涂片中发现利什曼原虫体，确诊为内脏利什曼病。鉴定出12只白蛉为亚历山大白蛉，其中1只白蛉发现有前鞭毛体自然感染。
调查证实内脏利什曼病在哈满沟煤矿区为地方性流行。
