Shenyang Pharmaceutical University, School of Pharmacy, Department of Pharmaceutics, 103 Wenhua Road, Shenyang, Liaoning 110016, PR China.
Expert Opin Drug Deliv. 2009 Nov;6(11):1247-59. doi: 10.1517/17425240903206963.
Evidence that small molecules extracted from traditional Chinese medicines (TCMs) have beneficial effects on health is increasingly being reported in the scientific literature and these compounds are now widely recognized as potential therapeutic drugs. There have been several detailed studies of the absorption, distribution, metabolism and excretion of these compounds in rats and humans. However, some active components have low bioavailability owing to their unsuitable physicochemical and biopharmaceutical characteristics, resulting in differences in vivo. The main problem in using natural products as a source of pharmaceutical lead compounds is the need to improve the bioavailability of these compounds. This review presents and discusses the current methods used for improvement and their impact on the bioavailability of some new pharmaceutical lead compounds from TCMs.
越来越多的科学文献报道了从中药中提取的小分子对健康有有益影响，这些化合物现在被广泛认为是有潜力的治疗药物。已经有一些关于这些化合物在大鼠和人体中的吸收、分布、代谢和排泄的详细研究。然而，由于某些活性成分的理化和生物药剂学特性不合适，导致其生物利用度较低，从而在体内产生差异。使用天然产物作为药物先导化合物的来源的主要问题是需要提高这些化合物的生物利用度。本综述介绍和讨论了目前用于提高这些化合物生物利用度的方法及其对一些来自中药的新药物先导化合物的影响。
