Feng Jian, Xie Ping
Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan, China.
Zhongguo Zhong Yao Za Zhi. 2003 Sep;28(9):798-800, 890.
Biological activity and physicochemical properties are two key factors to screen active compounds of traditional Chinese herbs during early discovery phases. As a great number of the compounds are got in the world, a new strategy is developed to research the physicochemical properties of the compositions of herbs, so that the election of active compounds from the compositions has become more effective and more economical than before. The new strategy and associated technology have emerged and it was used extensively. The physicochemical properties of the compounds of traditional Chinese medicine(TCM) relate to pharmaceutical and ADME (Absorption, distribution, metabolism and elimination), and development, clinical effect and safety are evaluated with the properties. Therefore, the physicochemical properties are important in the development of TCM.
生物活性和理化性质是中药活性成分早期发现阶段筛选的两个关键因素。由于世界上已获得大量化合物，因此开发了一种新策略来研究草药成分的理化性质，从而使从这些成分中筛选活性化合物变得比以往更加有效和经济。新策略及相关技术已经出现并得到广泛应用。中药化合物的理化性质与药物及ADME（吸收、分布、代谢和排泄）相关，并且利用这些性质来评估药物的研发、临床疗效和安全性。因此，理化性质在中药研发中很重要。
