上皮-间充质转化在小鼠乳腺肿瘤发生中的作用。

Epithelial-mesenchymal transition in mouse mammary tumorigenesis.

机构信息

Department of Veterinary Pathology, Hygiene and Public Health, Section of Veterinary and Avian Pathology, Faculty of Veterinary Medicine, University of Milan, Via Celoria, 10 20133 Milano, Italy.

出版信息

Future Oncol. 2009 Oct;5(8):1113-27. doi: 10.2217/fon.09.93.

DOI:10.2217/fon.09.93

PMID:19852725

Abstract

Epithelial-mesenchymal transition tumorigenesis in the mouse has been described for over 100 years using various terms and with little comprehension of the underlying mechanisms. Recently, epithelial-mesenchymal transition tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective and the current observations in the context of some of the key molecular biology. The biology of mouse mammary epithelial-mesenchymal transition tumorigenesis is discussed with comparisons to human breast cancer.

摘要

上皮-间充质转化肿瘤发生在老鼠身上已经有 100 多年的历史了，使用了各种术语，但对潜在机制的理解却很少。最近，在基因工程小鼠的乳腺中已经发现了上皮-间充质转化肿瘤。本文在一些关键分子生物学的背景下提供了一个历史视角和当前的观察结果。讨论了小鼠乳腺上皮-间充质转化肿瘤发生的生物学特性，并与人类乳腺癌进行了比较。