Gray F, Chimelli L, Mohr M, Clavelou P, Scaravilli F, Poirier J
Département de Pathologie (Neuropathologie), Hôpital Henri Mondor, Creteil, France.
Neurology. 1991 Jan;41(1):105-9. doi: 10.1212/wnl.41.1.105.
A 66-year-old French homosexual man and a 42-year-old Brazilian man with no known risk factors for HIV infection developed headaches, asthenia, and neurologic episodes of abrupt onset. CT showed multiple hypodense, nonenhancing lesions. Serology for HIV was positive. They died respectively 2 months and 1 month after onset of the illnesses. Autopsy in both cases showed multiple, well-demarcated, demyelinating foci in the white matter of the cerebral hemispheres, brainstem, and cerebellum with histologic features characteristic of recent plaques of multiple sclerosis. There were no multinucleated giant cells or microglial nodules. Immunostaining for HIV was negative. Although a random coincidence of MS and HIV infection cannot be ruled out, the close temporal relationship between the 2 disorders suggests a possible etiologic association.
一名66岁的法国同性恋男子和一名42岁的巴西男子，无已知的HIV感染风险因素，出现头痛、乏力以及突发的神经系统症状。CT显示多个低密度、无强化病灶。HIV血清学检测呈阳性。他们分别在发病后2个月和1个月死亡。两例尸检均显示大脑半球、脑干和小脑白质中有多个界限清楚的脱髓鞘病灶，具有近期多发性硬化斑块的组织学特征。没有多核巨细胞或小胶质结节。HIV免疫染色为阴性。虽然不能排除多发性硬化症（MS）与HIV感染的随机巧合，但这两种疾病之间密切的时间关系提示可能存在病因学关联。
