Nanomolecular targeting of dendritic cells for ovarian cancer therapy.
作者信息
Cubillos-Ruiz Juan R, Fiering Steven, Conejo-Garcia Jose R
出版信息
Future Oncol. 2009 Oct;5(8):1189-92. doi: 10.2217/fon.09.101.
Abstract
摘要
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Cancer Res. 2009 Sep 15;69(18):7329-37. doi: 10.1158/0008-5472.CAN-09-0835. Epub 2009 Sep 8.
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Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity.基于聚乙烯亚胺的小干扰RNA纳米复合物通过Toll样受体5重编程肿瘤相关树突状细胞，以引发治疗性抗肿瘤免疫。
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CCL5-mediated endogenous antitumor immunity elicited by adoptively transferred lymphocytes and dendritic cell depletion.通过过继转移淋巴细胞引发的CCL5介导的内源性抗肿瘤免疫及树突状细胞耗竭。
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