Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, SI-1000 Ljubljana, Slovenia.
Biol Chem. 2011 Nov;392(11):955-60. doi: 10.1515/BC.2011.185.
The development of new and effective drug delivery systems for cancer treatment represents one of the significant challenges facing biomedical technology in the last decade. Among the different methods of drug delivery, magnetic drug targeting, by enabling specific delivery of chemotherapeutic agents through the use of magnetic nanoparticles and magnetic field gradient, could be a promising approach. Recently, magnetic nanoparticles have attracted additional attention because of their potential as contrast agents for magnetic resonance imaging and heat mediators for cancer therapy. This review summarizes these approaches in the use of magnetic nanoparticles in biomedical applications and novel methods for their optimization.
新型有效癌症治疗药物输送系统的开发是过去十年生物医学技术面临的主要挑战之一。在药物输送的各种方法中,通过使用磁性纳米粒子和磁场梯度实现化疗药物的靶向输送的磁性药物靶向治疗可能是一种很有前途的方法。最近,磁性纳米粒子因其作为磁共振成像对比剂和癌症治疗热介质的潜力而受到更多关注。本综述总结了这些在生物医学应用中使用磁性纳米粒子的方法以及优化这些方法的新方法。