通过微小RNA调节重编程免疫反应。
Reprogramming immune responses via microRNA modulation.
作者信息
Cubillos-Ruiz Juan R, Rutkowski Melanie R, Tchou Julia, Conejo-Garcia Jose R
机构信息
Department of Medicine, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA ; The Ragon Institute of MGH, MIT and Harvard. 149 13th Street, Charlestown, MA 02129, USA.
Tumor Microenvironment and Metastasis Program, The Wistar Institute, 3601 Spruce St, Philadelphia, PA 19104, USA.
出版信息
Microrna Diagn Ther. 2013 Apr 26;1(1). doi: 10.2478/micrnat-2013-0001.
Abstract
It is becoming increasingly clear that there are unique sets of miRNAs that have distinct governing roles in several aspects of both innate and adaptive immune responses. In addition, new tools allow selective modulation of the expression of individual miRNAs, both in vitro and in vivo. Here, we summarize recent advances in our understanding of how miRNAs drive the activity of immune cells, and how their modulation in vivo opens new avenues for diagnostic and therapeutic interventions in multiple diseases, from immunodeficiency to cancer.
摘要
越来越明显的是，存在独特的一组组微小RNA（miRNA），它们在先天性和适应性免疫反应的多个方面发挥着不同的调控作用。此外，新工具能够在体外和体内对单个miRNA的表达进行选择性调控。在这里，我们总结了近期在理解miRNA如何驱动免疫细胞活性以及其在体内的调控如何为从免疫缺陷到癌症等多种疾病的诊断和治疗干预开辟新途径方面所取得的进展。
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